C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01)
Patent
CA 2675192
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding Qpct proteins, which have been implicated in Qpct-related diseases. The present invention additionally provides cells and cell lines comprising transgenes encoding for Qpct. The present invention further provides methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.
La présente invention porte sur un non-humain transgénique, en particulier une souris transgénique, codant pour des protéines Qpct qui ont été impliquées dans des maladies apparentées à Qpct. De plus, la présente invention porte sur des cellules et des lignées cellulaires comprenant des transgènes codant pour Qpct. La présente invention porte, en outre, sur des procédés et des compositions permettant d'évaluer des agents qui affectent Qpct en vue de les utiliser dans des compositions thérapeutiques de maladies apparentées à Qpct.
Cynis Holger
Demuth Hans-Ulrich
Hoffmann Torsten
Schilling Stephan
Schulz Katrin
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Probiodrug Ag
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