In vivo temporal control of activatable matrix-degrading...

Details In vivo temporal control of activatable matrix-degrading... In vivo temporal control of activatable matrix-degrading...

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61P 1/00 (2006.01) A61P 17/02 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2718549

Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading en-zymes. The methods and combinations permit temporary in- vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or "ECM"). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM--mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.

La présente invention concerne des procédés et des combinaisons pour contrôler la durée daction, in vivo, denzymes de dégradation de matrice. Les procédés et combinaisons permettent temporairement lactivation in vivo denzymes de dégradation de matrice après administration dans la matrice extracellulaire (ou « ECM »). Des enzymes de dégradation de matrice ayant une durée daction contrôlée peuvent être utilisées pour traiter des maladies ou troubles véhiculés par lECM caractérisés par un dépôt ou une accumulation augmentés dun ou plusieurs composants de lECM.

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