In vivo tumor targeting and spectroscopic detection with...

Details In vivo tumor targeting and spectroscopic detection with... In vivo tumor targeting and spectroscopic detection with...

B - Operations, Transporting

82

B

B82B 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 21/65 (2006.01)

Patent

CA 2682408

Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a metallic gold surface- enhanced Raman scattering nanoparticle, a Raman reporter and a protection structure. The protection structure may include a thiol-polyethylene glycol to which may be attached a target-specific probe.

L'invention porte sur des nanostructures, des procédés de préparation de nanostructures, des procédés de détection de cibles chez un sujet et des procédés de traitement des maladies chez un sujet. Dans un mode de réalisation desdites nanostructures, on trouve une nanoparticule métallique en or à diffusion Raman améliorée en surface, un reporter de Raman et une structure de protection. La structure de protection peut comprendre un thiol polyéthylène-glycol auquel peut être fixée une sonde spécifique à la cible.

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