Inactivating pathogens with hydrogen peroxide for vaccine...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 9/19 (2006.01) A61K 39/002 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/285 (2006.01) A61L 2/20 (2006.01) A61P 37/04 (2006.01) C12N 1/36 (2006.01) C12N 7/06 (2006.01)

Patent

CA 2618306

The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathogens, including viruses, bacteria and parasites. The disclosure also provides vaccine compositions (medicaments) containing a pathogen inactivated by exposure to hydrogen peroxide. Methods for eliciting an immune response in a subject by administering vaccine compositions containing a hydrogen peroxide inactivated pathogen are also provided.

La présente invention concerne des procédés destinés à produire une composition de vaccin, contenant un agent pathogène qui est rendu non infectieux par exposition à du peroxyde d'hydrogène. Les procédés présentés ici sont adaptés à la préparation de vaccins concernant une large variété d'agents pathogènes, y compris des virus, des bactéries et des parasites. La présente invention concerne également des compositions de vaccin (médicaments) contenant un agent pathogène inactivé par exposition à du peroxyde d'hydrogène. Enfin, l'invention concerne des procédés destinés à provoquer une réponse immune chez un sujet, par administration de compositions de vaccin contenant un agent pathogène inactivé par du peroxyde d'hydrogène.

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