Inactivation of genes of the mep pathway

Details Inactivation of genes of the mep pathway Inactivation of genes of the mep pathway

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 31/66 (2006.01) A61K 35/68 (2006.01) A61K 35/74 (2006.01)

Patent

CA 2444955

The invention relates to cells and organisms as well as to methods for producing said cells and organisms, according to which intermediates of the mevalonate-independent pathway for isoprenoid biosynthesis (MEP pathway) are enriched by deleting or inactivating genes. The derivatives can also be enriched by using enzyme inhibitors. The enriched intermediates may be used as substrates in enzyme activity tests. The inventive cells and organisms and the enriched intermediates can further be used in the production of medicaments.

La présente invention concerne des cellules et des organismes ainsi que des procédés de production de ces cellules et organismes caractérisés en ce qu'ils permettent d'enrichir des intermédiaires de la voie de biosynthèse des isoprénoïdes indépendante du mévalonate (voie MEP) par délétion ou inactivation de gènes desdits organismes et cellules. L'utilisation d'inhibiteurs enzymatiques permet également d'enrichir lesdits dérivés. Les intermédiaires enrichis peuvent servir de substrat dans des tests de l'activité enzymatique. En outre, les cellules et organismes selon la présente invention ainsi que les intermédiaires enrichis peuvent être utilisés pour produire des substances pharmaceutiques.

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