Inactivation of viruses by incubation with caprylate

Details Inactivation of viruses by incubation with caprylate Inactivation of viruses by incubation with caprylate

A - Human Necessities

61

L

A61L 2/18 (2006.01) A61K 38/38 (2006.01) A61L 2/00 (2006.01) C07K 14/76 (2006.01) C07K 14/765 (2006.01)

Patent

CA 2273924

The present invention provides a method of inactivating lipid-enveloped virus in a solution of therapeutic protein. The method comprises incubating the solution at temperature greater than 15 ~C at a pH in the range of about 4.0 to about 6.0 with caprylate at a concentration of at least about 6mM. The pH and caprylate concentration are selected such that the caprylic acid concentration is greater than 0,07 % w/w.

L'invention concerne un procédé servant à inactiver un virus à enveloppe lipidique dans une solution de protéine thérapeutique. Ce procédé consiste à effectuer l'incubation de la solution à une température supérieure à 15 ·C à un pH situé dans une plage de 4 à 6 avec caprylate à une concentration d'au moins 6mM. On sélectionne le pH et la concentration de caprylate de sorte que la concentration d'acide caprylique est supérieure à 0,07 % en poids.

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