Incapacitated whole-cell immunogenic bacterial compositions

Details Incapacitated whole-cell immunogenic bacterial compositions Incapacitated whole-cell immunogenic bacterial compositions

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/02 (2006.01) C12N 1/00 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2461710

The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys minus bacteriophage retain activity in infection of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. The resulting, Lys minus-infected bacterium is provided in a state of bacteriostasis, and is not capable of replicating further (e.g., is "incapacitated"). The incapacitated bacterium can then be used as to elicit an immune response for prophylactic and/or therapeutic purposes. The invention thus also features incapacitated bacteria formulated appropriately for use in immunogenic compositions for eliciting an immune response, e.g., for production of antibodies in a non-human host or in a whole cell bacterial vaccine.

L'invention porte sur des compositions immunogènes de cellules entières de bactéries rendues incapables par infection par un bactériophage Lys minus déficient en lysine. Ledit bactériophage agit en infectant un hôte bactérien approprié, en détruisant son génome et ses possibilités de réplication. Une bactérie infectée par le Lys-minus présente un état de bactériostase et n'est plus capable de réplication (on la dit "incapable"); elle peut servir à susciter une réponse immunitaire à des fins prophylactiques et/ou thérapeutiques. L'invention porte également sur une bactérie rendue incapable traitée pour entrer dans la formule de compositions suscitant une réponse immunitaire, par exemple pour produire des anticorps dans un hôte non humain ou un vaccin antibactérien à cellules entières.

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