Inclusion complex containing indole selective serotonin agonist

Details Inclusion complex containing indole selective serotonin agonist Inclusion complex containing indole selective serotonin agonist

A - Human Necessities

61

K

A61K 47/40 (2006.01) A61K 31/137 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/20 (2006.01) A61K 31/245 (2006.01) A61K 31/277 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/403 (2006.01) A61K 31/4045 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/4422 (2006.01) A61K 31/445 (2006.01) A61K 31/4468 (2006.01) A61K 31/451 (2006.01) A61K 31/454 (2006.01) A61K 31/455 (2006.01) A61K 31/485 (2006.01) A61K 31/495 (2006.01) A61K 31/575 (2006.01) A61K 31/724 (2006.01) A61K

Patent

CA 2257860

An inclusion complex comprises (a) an indole selective serotonin (5-HTID) agonist or a pharmaceutically acceptable salt thereof, such as for example sumatriptan, and (b) unsubstituted or substituted beta- or gamma-cyclodextrin, such as for example methyl-beta-cyclodextrin. Pharmaceutical compositions containing the inclusion complex and the use of the inclusion complex in the treatment of migraine and cluster headaches are also disclosed.

Un composé d'inclusion comprend (a) un antagoniste (5-HT¿ID?) sélectif de la sérotonine à structure indole ou un sel pharmaceutiquement acceptable dudit composé, comme, par exemple, le sumatriptan, et (b) une béta- ou gamma- cyclodextrine comme, par exemple, méthyl-béta-cyclodextrine. L'invention concerne aussi des compositions pharmaceutiques contenant le composé d'inclusions et l'utilisation du composé d'inclusion dans le traitement de la migraine et de la céphalée en salve.

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