Inclusion complex of cyclodextrin and indomethacin and a...

Details Inclusion complex of cyclodextrin and indomethacin and a... Inclusion complex of cyclodextrin and indomethacin and a...

A - Human Necessities

61

K

195/131, 260/207

A61K 31/70 (2006.01) A61K 31/405 (2006.01) A61K 47/48 (2006.01) C07D 209/28 (2006.01) C08B 37/00 (2006.01) C08B 37/16 (2006.01)

Patent

CA 1119115

ABSTRACT OF THE DISCLOSURE The invention relates to an inclusion complex of 1-(p-chloro-benzoyl)-5-methoxy-2-methyl-indol-3-yl-acetic acid (?ndomethacin) and cyclodextrin of a molar ratio of about 2:1. The inclusion complex can be prepared by reacting about 2 moles of alpha or beta cyclodextrin with about 2 mole of 1-(p-chloro-benzoyl)-5-methoxy-2-methyl- indol-3-yl-acetic acid under heating in the presence of an organic solvent which dissolves indo?ehtacin and does not form a stable complex with cyclodextrin. The new complex is at least ?? active antiinfl??matory agent as indometh?cin and at the same time shows substantially less ulcerative side-effect.

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