C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/16 (2006.01) A61K 31/42 (2006.01) A61K 31/424 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2100045
22 ABSTRACT Described is a new process for the preparation of alkali clavulanate from an aqueous solution of crude clavulanic acid, which is obtained in a conventional manner after the fermentation with a clavulanic-acid-producing microorganism, extracted with an ethyl acetate solution of a hydrophobic .beta.-CD derivative such as heptakis-(2,3,6-tri- O-acetyl)-.beta.-CD in at least equimolar ratio with regard to clavulanic acid. The result- ing novel inclusion complexes of clavulanic acid and hydrophobic .beta.-CD derivative in a molar ratio about 1:1 are isolated, purified and then converted with an alkali base or alkali alkanoate to the desired alkali clavulanate, which is isolated. Furthermore, there are described new inclusion complexes of clavulanic acid and of its pharma- ceutically acceptable alkali salts both with hydrophilic .beta.-CD derivatives and with hydrophobic .beta.-CD derivatives, processes for the preparation thereof and the use thereof for the preparation of galenic forms with immediate as well as with sustained action, in combination with amoxicillin trihydrate, which are valuable medicaments in the therapy of infectious diseases.
Fercej-Temeljotov Darja
Kotnik Sonja
Kovacic Mateja
Verhnjak Katarina
Zmitek Janko
Ljubljana Lek Tovarna Farmacevtskih In Kemicnih Izdelkov,d.d.
Sim & Mcburney
LandOfFree
Inclusion complexes of clavulanic acid and of alkali salts... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inclusion complexes of clavulanic acid and of alkali salts..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inclusion complexes of clavulanic acid and of alkali salts... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2036819