Inclusion complexes of taxol or taxotere or taxus extract...

Details Inclusion complexes of taxol or taxotere or taxus extract... Inclusion complexes of taxol or taxotere or taxus extract...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01) A61K 31/715 (2006.01) A61K 47/48 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2162716

The invention relates to the inclusion complexes of Taxol or Taxotere and Taxus extracts (comprising besides taxol other diterpene taxan-drivatives) formed with a cyclodextrin derivative or cyclodextrin- derivative-mixture. According to the invention, improved aqueous solubility of Taxol and Taxan-derivatives can be reached by using suitable cyclodextrins and/or cyclodextrin derivatives and/or mixtures thereof. The inclusion complexes can be prepared in an aqueous medium, in solid form or by high energy milling. The pharmaceutical compositions according to the invention bear an outstanding importance in treatment of cancer.

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