Increase in hematopoietic progenitor cells in peripheral...

Details Increase in hematopoietic progenitor cells in peripheral... Increase in hematopoietic progenitor cells in peripheral...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 35/14 (2006.01) A61M 1/38 (2006.01)

Patent

CA 2170979

TGF.beta. is used to increase the numbers of stem cells in a subject's peripheral blood. Then the subject's blood is drawn and the stem cells removed. After myelosuppressive therapy is administered to the subject, the stem cells are administered to the subject. An alternate method provides for TGF.beta. administration to a donor subject whose blood is drawn and from whose blood the stem cells are removed; after a recipient subject receives myelosuppressive therapy, the stem cells are administered to the recipient subject.

Le facteur transformant de croissance bêta est utilisé pour augmenter le nombre de cellules souches dans le sang périphérique d'un sujet. Le sang du sujet est ensuite prélevé et les cellules souches sont extraites. Les cellules souches sont administrées au sujet après qu'il a subi une thérapie myélodépressive. Dans un autre mode de réalisation, le facteur transformant de croissance est administré à un sujet donneur dont le sang est prélevé et duquel les cellules souches sont extraites; les cellules souches sont administrées à un sujet receveur après qu'il a subi une thérapie myélodépressive.

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