Increased and sustained in vivo gene expression using a...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A01K 67/027 (2006.01) A61K 9/127 (2006.01) A61K 31/132 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) C12N 15/67 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2448863

The invention features a non-transgenic model of Alzheimer's Disease, methods for inducing increased and sustained in vivo gene expression in a mammal over a prolonged period of time using a composition comprising a nucleic acid, histone, and amphipathic compound, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.

Cette invention concerne un modèle non transgénique de la maladie d'Alzheimer, un méthode permettant d'induire une expression génique in vivo prolongée chez un mammifère et des méthodes propres à inhiber la mort de neurones associées à la maladie d'Alsheimer.

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