Increased bioavailability of biologically active compounds...

Details Increased bioavailability of biologically active compounds... Increased bioavailability of biologically active compounds...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/58 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07D 207/34 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 491/22 (2006.01) C07D 493/04 (2006.01) C07F 9/547 (2006.01) C07H 15/252 (2006.01) C07J 43/00 (2006.01) C07K 5/04 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01)

Patent

CA 2189358

A compound of formula (II) wherein R is an acidic group: m is an integer of 1 to 3; n is zero or an in- teger of 1 to 3; A is an enzymatically hydrolyzable spacer; and X is a bio- logically active compound; or a phar- maceutically acceptable salt thereof, for use as an antiproliferative, in par- ticular anti-tumor and anti-antiogenic agent, and anti-inflammatory agent, is provided.

Composé de la formule (II), dans laquelle R représente un groupe acide; m est un nombre entier de 1 à 3; n vaut zéro ou un nombre entier de 1 à 3; A représente un séparateur hydrolysable par voie enzymatique; et X représente un composé biologiquement actif; ou sel pharmaceutiquement acceptable de ce composé. Ce composé ou son sel est destiné à être utilisé comme agent antiprolifératif, en particulier comme agent antitumoral et anti-angiogène, ainsi que comme agent anti-inflammatoire.

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