Increased effectiveness of allylamine drug compounds

Details Increased effectiveness of allylamine drug compounds Increased effectiveness of allylamine drug compounds

A - Human Necessities

61

K

A61K 47/06 (2006.01) A61K 31/137 (2006.01) A61P 17/02 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2676975

The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages The allylamine active ingredient is prepared in an acidic environment, which alters the physiochemical properties of the active ingredient resulting in the ingredient having a positive charge The positive charge and enhancers used in the formula allo for increased penetration of the active ingredient through skin and skin appendages The positively charged active ingredients are eithe dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

Efficacité accrue de composés médicamenteux allylamine pour le traitement topique d'infections fongiques de la peau et des annexes cutanées. Le principe actif allylamine est préparé dans un environnement acide, qui modifie les propriétés physiochimiques du principe actif et lui donne une charge positive, laquelle, combinée à l'effet des activateurs utilisés dans la formule, accentue la pénétration du principe actif dans la peau et les annexes cutanées. Les principes actifs positivement chargés sont soit dissous dans le véhicule directement soit dissous dans plusieurs billes en suspension dans le véhicule. La structure des billes réduit au minimum la diffusion moléculaire du principe actif positivement chargé et d'une espèce catalytique dans cette structure, stabilisant ainsi ledit principe positivement chargé dans la bille en empêchant l'interaction du principe positivement chargé et de l'espèce catalytique, ce qui allonge la durée de vie du principe positivement chargé.

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