C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/16 (2006.01) C12N 9/88 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2735945
Yeast strains were engineered that have increased activity of heterologous proteins that require binding of an Fe-S cluster for their activity. The yeast strains have reduced activity of an endogenous Fe-S protein. Activities of heterologous fungal or plant 2Fe-2S dihydroxy-acid dehydratases and Fe-S propanediol dehydratase reactivase were increased for increased production of products made using biosynthetic pathways including these enzymes, such as valine, isoleucine, leucine, pantothenic acid (vitamin B5), isobutanol, 2-butanone and 2-butanol.
La présente invention concerne des souches de levure qui sont modifiées de manière à avoir une activité augmentée de protéines hétérologues qui requièrent la liaison dun groupement Fe-S pour leur activité. Les souches de levure ont une activité réduite dune protéine Fe-S endogène. Les activités de 2Fe-2S dihydroxy-acide déshydratases et de Fe-S propanediol déshydratase réactivase hétérologues de champignon ou de plante sont augmentées pour une production augmentée de produits formés en utilisant des voies biosynthétiques comprenant ces enzymes, tels que la valine, lisoleucine, la leucine, lacide pantothénique (vitamine B5), lisobutanol, la 2-butanone et le 2-butanol.
Anthony Larry Cameron
Maggio-Hall Lori Ann
Rothman Steven Cary
Tomb Jean-Francois
Butamax(tm) Advanced Biofuels Llc
Torys Llp
LandOfFree
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