C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) C07K 14/34 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/06 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12N 15/31 (2006.01) C12N 15/52 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) C12P 13/08 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2654770
The invention provides methods to increase the production of an amino acid from Corynebacterium species by way of the amplication of amino acid biosynthetic pathway genes in a host cell chromosome. In a preferred embodiment, the invention provides methods to increase the production of L-Lysine in Corynebacterium glutamicum by way of the amplification of L-lysine biosynthetic pathway genes in a host cell chromosome. The invention also provides novel processes for the production of an amino acid by way of the amplification of amino acid biosynthetic pathway genes in a host cell chromosome and/or by increasing promoter strength. In a preferred embodiment, the invention provides processes to increase the production of L-lysine in Corynebacterium glutamicum by way of the amplification of L-lysine biosynthetic pathway genes in a host cell chromosome. The invention also provides novel isolated nucleic acid molecules for L-lysine biosynthetic pathway genes of Corynebacterium glutamicum.
Crafton Corey M.
Hanke Paul D.
Li-D'elia Lhing-Yew
Rayapati P. John
Walsh Holly J.
Archer-Daniels-Midland Company
Gowling Lafleur Henderson Llp
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