C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C07K 14/34 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 9/02 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12N 15/31 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12N 15/60 (2006.01) C12P 13/08 (2006.01) C12Q 1/04 (2006.01)
Patent
CA 2396052
The invention provides methods to increase the production of an amino acid from < i > Corynebacterium < /i > species by way of the amplication of amino acid biosynthetic pathway genes in a host cell chromosome. In a preferred embodiment, the invention provides methods to increase the production of L-Lysine in < i > Corynebacterium glutamicum < /i > by way of the amplification of L-lysine biosynthetic pathway genes in a host cell chromosome. The invention also provides novel processes for the production of an amino acid by way of the amplification of amino acid biosynthetic pathway genes in a host cell chromosome and/or by increasing promoter strength. In a preferred embodiment, the invention provides processes to increase the production of L-lysine in < i > Corynebacterium glutamicum < /i > by way of the amplification of L- lysine biosynthetic pathway genes in a host cell chromosome. The invention also provides novel isolated nucleic acid molecules for L-lysine biosynthetic pathway genes of < i > Corynebacterium glutamicum < /i > .
L'invention concerne des procédés permettant d'augmenter la production d'un acide aminé à partir d'espèces <i>corynebacterium</i>par amplification de gènes de la voie biosynthétique d'acide aminé dans un chromosome d'une cellule hôte. Dans un mode de réalisation optimal, l'invention concerne des procédés permettant d'augmenter la production de L-lysine dans le <i>corynebacterium glutamicum</i> par amplification des gènes de la voie biosynthétique de L-lysine dans un chromosome de cellule hôte. L'invention concerne également des nouveaux procédés permettant de produire un acide aminé par amplification de gènes de la voie biosynthétique d'acide aminé dans un chromosome de cellule hôte et/ou par augmentation de la résistance des promoteurs. L'invention concerne également des nouvelles molécules d'acide nucléique isolées destinées aux gènes de la voie biosynthétique de <i>corynebacterium glutamicum</i>.
Crafton Corey M.
Hanke Paul D.
Li-D'elia Lhing-Yew
Rayapati P. John
Walsh Holly J.
Archer-Daniels-Midland Company
Gowling Lafleur Henderson Llp
LandOfFree
Increased lysine production by gene amplification does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Increased lysine production by gene amplification, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Increased lysine production by gene amplification will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1622181