Increased separation efficiency via controlled aggregation...

Details Increased separation efficiency via controlled aggregation... Increased separation efficiency via controlled aggregation...

G - Physics

01

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G01N 1/00 (2006.01) C12N 15/10 (2006.01) G01N 1/28 (2006.01) G01N 1/38 (2006.01) G01N 21/00 (2006.01) G01N 21/01 (2006.01) G01N 21/17 (2006.01) G01N 21/25 (2006.01) G01N 21/29 (2006.01) G01N 21/41 (2006.01) G01N 21/62 (2006.01) G01N 21/63 (2006.01) G01N 21/64 (2006.01) G01N 21/75 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01) G01N 33/532 (2006.01) G01N 33/533 (2006.01) G01N 33/536 (2006.01) G01N 33/537 (2006.01) G01N 33/539 (2006.01) G01N 33/542 (2006.01) G01N 33/543 (2006.01) G01N 33/563 (2006.01) G0

Patent

CA 2416277

Compositions and methods are disclosed which enhance the microscopic observation and analysis of biological entities such as cells, bacteria and viruses by eliminating interfering magnetic clusters created by naturally occurring aggregators of colloidal magnetic particles. Additionally means for significantly enhancing the magnetic isolation of low antigen density target cells from biological samples are disclosed.

La présente invention concerne des compositions et des procédés qui permettent une meilleure qualité des examens au microscope et de l'analyse d'entités biologiques (cellules, bactéries, virus, ...). On arrive en effet ainsi à éliminer les amas magnétiques indésirables provoqués par des agents existant à l'état naturel et ayant tendance à agréger les particules magnétiques colloïdales. L'invention concerne également des moyens permettant d'augmenter de façon notable l'isolation magnétique de cellules cibles à faible densité en antigène à partir des échantillons biologiques.

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