Increasing production of proteins in gram-positive...

Details Increasing production of proteins in gram-positive... Increasing production of proteins in gram-positive...

C - Chemistry, Metallurgy

12

N

C12N 15/74 (2006.01) C12N 1/21 (2006.01) C12N 9/90 (2006.01) C12N 15/61 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2296707

The present invention relates to secretion in Gram-positive microorganisms. The present invention provides the nuclei acid and amino acid sequences for the Bacillus subtilis disulfide bond isomerases, Dsb1 and Dsb2. The present invention also provides means for increasing the secretion of heterologous or homologous proteins in gram- positive microorganisms.

La présente invention concerne la sécrétion dans des micro-organismes Gram positif. Elle concerne également des séquences d'acides nucléiques et d'acides aminés, destinées aux isomérases à pont disulfure obtenues à partir de Bacillus subtilis, Dsb1 et Dsb2. L'invention concerne encore des moyens d'augmentation de la sécrétion de protéines hétérologues ou homologues dans des micro-organismes Gram positif.

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