C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) C12N 15/113 (2010.01) C12N 15/12 (2006.01) C12N 15/67 (2006.01) C12N 15/867 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2761435
The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50.
La présente invention concerne des procédés et des matériaux pour augmenter l'expression d'une protéine d'intérêt telle qu'un anticorps par une cellule. L'expression ou l'activité de ABC50 est augmentée, ce qui augmente l'expression de la protéine ou de l'anticorps d'intérêt. La présente invention concerne en outre des procédés et des matériaux pour augmenter la sensibilité d'une cellule à un agent stressant le réticulum endoplasmique tel que l'éconozole par diminution du taux de ABC50.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Health Network
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