Indan derivatives

Details Indan derivatives Indan derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/495 (2006.01) C07D 207/24 (2006.01) C07D 207/263 (2006.01) C07D 233/42 (2006.01) C07D 235/26 (2006.01) C07D 239/10 (2006.01) C07D 263/22 (2006.01) C07D 295/04 (2006.01) C07D 295/073 (2006.01) C07D 295/088 (2006.01) C07D 405/14 (2006.01) C07D 409/00 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2097715

5-Substituted trans-1-piperazinoindan derivatives having general formula (I), wherein X is halogen, trifluoromethyl, alkyl, alkylthio, alkyloxy, hydroxy, alkylsulphonyl, alkyl- or dialkylamino, trifluoromethylthio or cyano; R is hydrogen, or alkyl, alke- nyl, cycloalkyl, or cycloalkyl lower alkyl, optionally substituted with hydroxy, or R is a substituent (a), wherein n is an integer from 1 to 6; U is CH or N; Y is CH2, O, S or N-R1, R1 being hydrogen or cycloalkyl, cycloalkylmethyl, alkyl or alkenyl op- tionally substituted with hydroxy or an optionally substituted phenyl group; W is O or S; Z is -(CH2)4-, (b), (c), where R2 and R3 are hydrogen or lower alkyl, -CH=CH-, -CH=CH-CH2-, optionally substituted 1,2-phenylene, 1,2-C6H4CH2- (to form a quinazolidinone or -thione ring system) or 1,2-C6H4CO- (to form a quinazolidindion or thioxoquinazolidinon ring system); and Ar is an optionally substituted phenyl, thiophene or furane ring; are selective, centrally acting 5-HT2 antagon- ists useful in the treatment of anxiety, depression, sleeping disorders, negative symptoms of schizophrenia and migraine.

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