Indane derivatives

Details Indane derivatives Indane derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/07 (2006.01) A61K 31/18 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/415 (2006.01) A61P 25/00 (2006.01) C07C 311/24 (2006.01) C07D 231/18 (2006.01) C07D 307/64 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2758105

The present invention relates to anindane derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said indane derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.

La présente invention porte sur un dérivé d'indane selon la formule I, dans laquelle les variables sont telles que définies dans la description, ou sur un sel ou solvate pharmaceutiquement acceptable de celui-ci. La présente invention porte également sur une composition pharmaceutique comprenant un desdits dérivés d'indane ou plus, et sur leur utilisation en thérapie, par exemple dans le traitement ou la prévention de maladies psychiatriques dans lesquelles une augmentation des réponses synaptiques à médiation par les récepteurs AMPA est nécessaire, comprenant la schizophrénie, la dépression et la maladie d'Alzheimer.

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