C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/12 (2006.01) A61K 31/415 (2006.01) A61P 25/00 (2006.01) C07D 231/14 (2006.01) C07D 231/18 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2725538
The present invention relates to a heterocyclic derivative according to formula (I); wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.
La présente invention concerne un dérivé hétérocyclique selon la formule (I), les variables étant définies comme dans la description, ou un sel ou un solvate pharmaceutiquement acceptable de celui-ci. La présente invention concerne également une composition pharmaceutique qui comprend lesdits dérivés hétérocycliques, et leur utilisation en thérapie, par exemple, dans le traitement ou la prévention de maladies psychiatriques où une amélioration des réponses synaptiques médiées par les récepteurs AMPA est requise, y compris la schizophrénie, la dépression et la maladie dAlzheimer.
Gillespie Jonathan
Jamieson Craig
Maclean John Kinnaird Ferguson
Moir Elizabeth Margaret
Rankovic Zoran
Fetherstonhaugh & Co.
N.v. Organon
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