Indane dimer compounds and their pharmaceutical use

Details Indane dimer compounds and their pharmaceutical use Indane dimer compounds and their pharmaceutical use

C - Chemistry, Metallurgy

07

C

C07C 225/20 (2006.01) A61K 31/075 (2006.01) A61K 31/10 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/185 (2006.01) A61K 31/21 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 13/465 (2006.01) C07C 35/32 (2006.01) C07C 35/52 (2006.01) C07C 43/188 (2006.01) C07C 45/46 (2006.01) C07C 45/51 (2006.01) C07C 45/62 (2006.01) C07C 45/65 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 45/71 (2006.01) C07C 45/74 (2006.01) C07C 49/67 (2006.01) C07C 49/683 (2006.01) C07C 49/697 (2006.01)

Patent

CA 2239853

Indane dimer compounds of general formula 5, 6 or 9 and their pharma- ceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in formulae 5 and 9, R1 and R3 to R15, and in formula 6, R1, R2 and R4 to R15, are selected from one or more of the same or different of H, halo, hy- droxy, alkoxy, aryloxy acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino hydroxylamino, amine oxide groups, azo groups, cyano, hy- drazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, hete- rocyclic groups containing one or more heteroatoms selected from N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may be saturated or unsaturated, substituted alkyl or cycloalkyl groups which may be saturated or unsaturated. In formulae 5, 6 and 9, X is O, NR (wherein R is acyl, alkyl or sulphonate groups), S, SO or SO2. In formulae 5, 6 and 9, any one or more of R1, 1R1; R2, 1R2; R3 1R3; R9 1R9; R10, 1R10 and R14, 1R14 may together represent oxo.

L'invention concerne des composés dimères de l'indane de la formule générale 5, 6 ou 9 et leur utilisation pharmaceutique, en particulier pour assurer une activité de relaxation des muscles lisses et/ou de stabilisation des mastocytes et/ou anti-inflammatoire. Dans les formules 5 et 9, R<1> et R<3> à R<15> et dans la formule 6, R<1>, R<2> et R<4> à R<15> sont les mêmes ou différents et sont choisis parmi un ou plusieurs des groupes suivants: H, halo, hydroxy, alcoxy, aryloxy, acétoxy, carboxy, alkylcarbonyle, hydrocarbonyle, amino, amido, alkylamino, hydroxylamino, oxyde d'amine, azo, cyano, hydrazino, hydrazide, hydrazone, imide, iminoéther, uréyle, oxime, nitro, nitrate, nitrite, nitroso, nitrile, un groupe hétérocyclique contenant un ou plusieurs hétéroatomes choisis parmi N, O or S, aralkyle, mono- polybenzoïdaryle, aryle substitué, thiol, thiouréyle, phénylthiol, acide sulfonique, sulfoxyde, sulfone, alkyle contenant de 1 à 10 atomes de carbone ou cycloalkyle contenant 3 à 8 atomes de carbone et qui peut être saturé ou insaturé, ou encore alkyle ou cycloalkyle substitué qui peut être saturé ou insaturé. Dans les formules 5, 6 et 9, X est O, NR (R est un groupe acyle, alkyle ou sulfonate), S, SO ou SO2. Dans les formules 5, 6 et 9, un ou plusieurs d'entre R<1>, <1>R<1>; R<2>, <1>R<2>; R<3>, <1>R<3>; R<9>, <1>R<9>; R<10>, <1>R<10> et R<14>, <1>R<14> peuvent représenter ensemble le groupe oxo.

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