Indane or dihydroindole derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 317/66 (2006.01) A61K 31/495 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2275299

The present invention relates to substituted indane or dihydroindole compounds of Formula (I), wherein A and B are independently O or S; D is an optionally substituted methylene group; X is N or optionally substituted C; and W is a spacer group. The compounds are either selective dopamine D4 ligands or they have combined effects at dopamine D4 and serotonergic receptors and/or the serotonergic transporter. These compounds are therefore useful in the treatment of certain psychiatric and neurologic disorders, including psychosis, depression and anxiety.

Composés d'indane ou de dihydroindole substitués, représentés par la formule (I). Dans ladite formule, A et B sont indépendamment O ou S; D est un groupe méthylène éventuellement substitué; X est N ou C éventuellement substitué; et W est un groupe séparateur. Soit les composés sont des ligands sélectifs de la dopamine D¿4?, soit ils ont des effets combinés au niveau des récepteurs de la dopaminergiques D¿4? et des récepteurs sérotoninergiques et/ou du transporteur sérotoninergique. Les composés considérés sont donc utiles dans le traitement de certaines maladies psychiatriques et neurologiques, parmi lesquelles figurent la psychose, la dépression et l'anxiété.

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