Indanone potentiators of metabotropic glutamate receptors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 257/04 (2006.01)

Patent

CA 2574971

The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

La présente invention est orientée vers des composés qui sont des facteurs de potentialisation de récepteurs métabotropiques de glutamates, y compris le récepteur de mGluR2, et qui sont utiles dans le traitement ou dans la prévention d'affections neurologiques et psychiatriques associées à un dysfonctionnement de glutamate, ainsi que de maladies dans lesquelles sont impliqués les récepteurs métabotropiques de glutamates. L'invention est également orientée vers des compositions pharmaceutiques comprenant ces composés et vers l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles sont impliqués les récepteurs métabotropiques de glutamates.

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