Indanpentol derivatives

Details Indanpentol derivatives Indanpentol derivatives

C - Chemistry, Metallurgy

07

D

260/292, 260/393

C07D 295/08 (2006.01) C07C 17/32 (2006.01) C07C 31/137 (2006.01) C07D 211/42 (2006.01) C07D 211/70 (2006.01) C07D 213/20 (2006.01) C07D 295/03 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1095037

Abstract This invention provides compounds having the structure Image herein R1, R2, R3, R4 and R5 are the same or different are hydrogen, lower alkyl, halo-lower alkyl, mono-halo-lower alkyl wherein the halogen is F, Cl, Br or I, acyl, amido Image , lower alkoxyalkylene or lower alkoxy carbonyl, X is a straight or branched chain alkylene group of the structure (CH2)n, wherein n' is 0 to 10, Y is Image wherein R7 and R8 are the same or different and are hydrogen, lower alkyl, halo-lower alkyl, monocyclic cycloalkyl having 3 to 6 ring members, mono- cyclic cycloalkyl-lower alkyl wherein the cycloalkyl has 3 to 6 ring members, hydroxy-lower alkyl, phenyl, lower alkylplenyl, acyl, di(lower alkyl)phenyl, halophenyl, mono-, di- or tri- nitrophenyl, phenyl-lower alkyl, monocyclic heterocyclic; wheroin lower alkyl contains 1 to 8 carbons, R6 is lower alkyl or cycloalkyl having 3 to 6 ring members, or Image can be taken together to form a heterocyclic radical; wherein the heterocyclic radicals represented by R7, R8 or Image taken together contain 5-, 6- or 7-members in the heterocyclic ring which may be substituted or unsubstituted, the ring being pyrrolidine, piperidine, morpholine, thiamorpholine, pipera- zine or homopiperazine and n is 1 to 3; m is 0, 1 or 2: stereo- isomers thereof, physiologically acceptable acid salts thereof, physiologically acceptable quaternary salts thereof and N-oxides thereof and a process for preparing these compounds which are useful in the treatment of hypertension.

269135

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