C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/16 (2006.01) A61K 31/18 (2006.01) A61K 31/445 (2006.01) C07C 311/20 (2006.01) C07C 311/21 (2006.01) C07C 311/26 (2006.01) C07C 311/29 (2006.01) C07C 311/39 (2006.01) C07D 217/02 (2006.01) C07D 295/22 (2006.01) C07D 295/26 (2006.01)
Patent
CA 2377087
The invention relates to compounds of formula (I), wherein R(1) to R(8) have the meanings given in the claims. Said compounds act upon the Kv1.5 potassium canal and inhibit a potassium flux, known as an "ultra-rapidly activating delayed rectifier" in the human atrium. The compounds are therefore particularly suitable for use as novel anti-arrhythmic active ingredients, in particular, for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
L'invention concerne des composés correspondant à la formule (I), dans laquelle les symboles R(1) à R(8) correspondent aux définitions données dans les revendications. Ces composés agissent sur le canal potassique Kv1.5 et inhibent un courant de potassium appelé "rectifieur à retard agissant ultrarapidement" dans l'oreillette de l'homme. Ces composés conviennent donc tout particulièrement comme nouveaux principes actifs antiarythmie, notamment pour le traitement et la prophylaxie d'arhytmies auriculaires par exemple la fibrillation auriculaire ou le flutter auriculaire.
Brendel Joachim
Gerlach Uwe
Lang Hans-Jochen
Ulrich Stilz Hans
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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