C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/10 (2006.01) A61K 31/497 (2006.01) A61P 9/10 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2629342
Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)- pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)- pyrazines, are disclosed herein.
La présente invention concerne des procédés d'utilisation d'(indazol-5-yl)-pyrazines et de (1,3-dihydro-indol-2-one)-pyrazines pour traiter des maladies ou des conditions à médiation de rho-kinase, y compris le contrôle de pression intra-oculaire et le traitement du glaucome. Sont présentées des compositions pharmaceutiques ophthalmiques utiles dans le traitement de maladies oculaires telles que le glaucome et utiles par ailleurs pour contrôler la pression intraoculaire, ces compositions comprenant une quantité effective d~(indazol-5-yl)-pyrazines et d~(1,3-dihydro-indol-2-un)-pyrazines.
Chen Hwamg-Hsing
Hellberg Mark R.
May Jesse A.
Rusinko Andrew
Sharif Najam A.
Alcon Research Ltd.
Kirby Eades Gale Baker
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