C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/416 (2006.01) A61K 31/5377 (2006.01) A61P 15/10 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 231/56 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2568050
The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.
La présente invention concerne des composés représentés par la formule générale (I), en l'occurrence une classe d'agonistes de la dopamine, et plus particulièrement une classe d'agonistes sélectifs pour D3 par rapport à D2. Ces composés trouvent leur utilité en traitement et/ou prévention de troubles sexuels, féminins tels que d'alerte sexuelle, de manque de désir sexuel ou d'absence d'orgasme, ou masculins tels que les troubles de l'érection. Les troubles masculins sont mentionnés ici pour tenir compte des troubles de l'éjaculation tels que l'éjaculation précoce, l'anorgasmie (impossibilité d'atteindre l'orgasme), ou les troubles du désir tels que la baisse de la libido. Ces composés conviennent pour le traitement de troubles neuropsychiatriques et neurodégénératifs.
Allerton Charlotte Moira Norfor
Hepworth David
Miller Duncan Charles
Pfizer Inc.
Torys Llp
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