C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/416 (2006.01) A61K 31/4184 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 231/56 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2383630
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
L'invention concerne des composés d'indazole qui modulent et/ou inhibent l'activité de certaines protéines kinases. Ces composés et les compositions pharmaceutiques qui les contiennent sont capables d'intervenir dans la transduction du signal de tyrosine kinase, et de moduler et/ou d'inhiber de cette manière une prolifération cellulaire indésirable. L'invention a également trait à l'utilisation thérapeutique ou prophylactique de compositions pharmaceutiques contenant ces composés, et à des méthodes de traitement du cancer et d'autres affections associées à une angiogenèse et/ou à une prolifération cellulaire indésirables, telles que la rétinopathie diabétique, le glaucome néovasculaire, la polyarthrite rhumatoïde et le psoriasis, par l'administration de quantités efficaces de ces composés.
Bender Steven Lee
Borchardt Allen J.
Braganza John F.
Collins Michael Raymond
Cripps Stephan James
Agouron Pharmaceuticals Inc.
Smart & Biggar
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