C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2722923
Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
La présente invention concerne des composés indazole qui sont utiles comme antagonistes de lactivité des récepteurs CCR1 et qui sont donc utiles pour le traitement dune variété de maladies et daffections qui sont médiées ou soutenues par le biais de lactivité des récepteurs CCR1, parmi lesquelles les maladies auto-immunes telles que la polyarthrite rhumatoïde et la sclérose en plaques. Linvention concerne également des compositions pharmaceutiques comprenant ces composés, des méthodes dutilisation de ces composés dans le traitement de diverses maladies et affections, des procédés de préparation de ces composés et des intermédiaires utiles dans ces procédés.
Disalvo Darren
Kuzmich Daniel
Mao Can
Razavi Hossein
Sarko Christopher
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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