C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2388885
Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating , e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
L'invention concerne des composés d'indazole qui modulent et/ou inhibent la prolifération cellulaire, telle que l'activité des protéines kinases. Ces composés et les compositions pharmaceutiques contenant ceux-ci sont capables de médier, par exemple, des maladies dépendantes des kinases afin de moduler et/ou d'inhiber une prolifération cellulaire indésirable. Cette invention concerne également l'utilisation thérapeutique ou prophylactique de compositions contenant ces composés, et des méthodes de traitement du cancer ainsi que d'autres états pathologiques associés à une angiogenèse et/ou à une prolifération cellulaire indésirable, telle que la rétinopathie diabétique, le glaucome néovasculaire, l'arthrite rhumatoïde, et le psoriasis, par administration de doses efficaces de ces composés.
Bleckman Ted Michael
Kephart Susan Elizabeth
Reich Siegfried Heinz
Romines William Henry III
Wallace Michael B.
Agouron Pharmaceuticals Inc.
Smart & Biggar
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