Indazole compounds useful as protein kinase inhibitors

Details Indazole compounds useful as protein kinase inhibitors Indazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 35/00 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2473986

The present invention provides compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R1, R2, V1, V2 and V3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.

L'invention concerne des composés de formule (I) ou un dérivé pharmaceutiquement acceptable de ceux-ci. Dans cette formule, R?1¿, R?2¿, V?1¿, V?2¿ et V?3¿ sont décrits dans la description. Ces composés sont des inhibiteurs de protéines kinases, en particulier des inhibiteurs kinases AKT, PKA, PDK1, p70S6K ou ROCK, de protéines kinases de mammifère impliquées dans des troubles prolifératifs et neurodégénératifs. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, et des procédés d'utilisation de ces compositions dans le traitement de troubles variés.

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