Indazole derivatives

Details Indazole derivatives Indazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 25/06 (2006.01) A61P 25/28 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2615611

This invention relates to compounds of the formula (I): (see formula I) or pharmaceutically acceptable salts thereof, wherein: R1, R2, R3, A and m are each as described herein and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome.

La présente invention concerne des composés de formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, où : R1, R2, R3, A et m sont chacun tels que décrits dans le présent document, ainsi que des compositions contenant ces composés et l~utilisation de ces composés dans le traitement d~une pathologie induite par l~activité agoniste 5-HT4 telle que, sans se limiter à, le reflux gastro-oesophagien, les troubles gastro-intestinaux, les troubles de la motilité gastrique, la dyspepsie non ulcéreuse, la dyspepsie fonctionnelle, le syndrome du côlon irritable, la constipation, la dyspepsie, l~oesophagite, les maladies gastro-oesophagiennes, la nausée, les maladies du système nerveux central, la maladie d'Alzheimer, les troubles cognitifs, les vomissements, la migraine, les maladies neurologiques, la douleur, les troubles cardiovasculaires, l~insuffisance cardiaque, l~arythmie cardiaque, le diabète et le syndrome de l~apnée .

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