Indazole derivatives as jnk inhibitors

Details Indazole derivatives as jnk inhibitors Indazole derivatives as jnk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/02 (2006.01) A61K 31/416 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) C07D 231/56 (2006.01) C07D 401/02 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/02 (2006.01) C07D 405/14 (2006.01) C07D 409/02 (2006.01) C07D 409/14 (2006.01) C07D 413/02 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2522682

This invention is generally directed to Indazole Derivatives having the following structure (I) or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

L'invention concerne des dérivés d'indazole représentés par la formule suivante (I) ou un sel pharmaceutiquement acceptable de ces dérivés. Dans ladite formule, R¿1?, R¿2? et A sont tels que définis dans le descriptif. Ces composés sont utiles dans le traitement d'une large gamme de maladies et de troubles qui sont sensibles à l'inhibition de la protéine JNK, tel qu'une maladie ou un trouble inflammatoire. L'invention concerne également des méthodes de traitement de ces maladies ou troubles ainsi que des compositions pharmaceutiques contenant un ou plusieurs composés ci-dessus.

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