Indazole derivatives that inhibit trpv1 and uses thereof

Details Indazole derivatives that inhibit trpv1 and uses thereof Indazole derivatives that inhibit trpv1 and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2661898

Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

L'invention concerne des composés de la formule (I), R3, R7, R9 et L étant définis dans la description, composés qui sont des antagonistes de TRPV1 présentant une faible activité inhibitrice contre CYP3A4. Des compositions comprenant de tels composés, et des procédés pour traiter des conditions et des troubles en utilisant de tels composés et compositions sont également décrits.

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