Indazoles, benzothiazoles, and benzoisothiazoles, and...

Details Indazoles, benzothiazoles, and benzoisothiazoles, and... Indazoles, benzothiazoles, and benzoisothiazoles, and...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2499128

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the .alpha.7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Cette invention concerne d'une manière générale le domaine des ligands des récepteurs nicotiniques de l'acétylcholine (nAChR), l'activation des récepteurs nAChR ainsi que le traitement d'états pathologiques associés à une défaillance ou un dysfonctionnement des récepteurs nicotiniques de l'acétylcholine, en particulier du cerveau. Cette invention concerne en outre de nouveaux composés (indazoles et benzothiazoles) qui agissent comme ligands du sous-type .alpha.7 du récepteur nAChR, des méthodes de préparation de ces composés, des compositions contenant ces composés ainsi que des procédés d'utilisation de ceux-ci.

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