Indazoles of cyclic ureas useful as hiv protease inhibitors

Details Indazoles of cyclic ureas useful as hiv protease inhibitors Indazoles of cyclic ureas useful as hiv protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 491/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2282593

The present invention describes indazoles of cyclic ureas of formula (I): wherein X is a linker group and Y may be acyclic or cyclic, which are useful as inhibitors of HIV protease, and pharmaceutical compositions and diagnostic kits comprising the same. One of D and D' is NH2 and the other selected from H, haloges, C1-6 alkoxy and C1-6 alygl.

La présente invention concerne des indazoles d'urées cycliques représentés par la formule (I), dans laquelle X est un groupe lieur, Y peut être acyclique ou cyclique, et l'un des deux éléments que sont D et D' est NH2, l'autre étant selectionné parmi H, un halogène, un groupe alcoxy C1-6 et un groupe alkyle C1-6 ces indazoles étant utiles comme inhibiteurs de VIH protéase. L'invention concerne des compositions pharmaceutiques et des trousses diagnostiques comportant celles-ci.

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