Indene and naphthalene derivatives

Details Indene and naphthalene derivatives Indene and naphthalene derivatives

C - Chemistry, Metallurgy

07

C

167/245, 167/264

C07C 259/04 (2006.01) A61K 31/155 (2006.01) C07C 259/18 (2006.01) C07C 281/18 (2006.01)

Patent

CA 1312871

INDENE and NAPHTHALENE DERIVATIVES ABSTRACT The invention relates to compounds of the general formula I Image wherein R1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO2, CF3 or the group -NR5R6, whereby two substituents taken together may also represent a methylene-dioxy group, X represents a member selected from Image , -CH2-CH2- and -CH=CH- , n has the value 0, 1 or 2, R3 represents one of the moieties: Image , Image or Image and R2, R4 , R5 and R6 represent hydrogen or alkyl(1-6C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heartfailure.

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