Indene derivatives and methods

Details Indene derivatives and methods Indene derivatives and methods

C - Chemistry, Metallurgy

07

C

260/295, 260/326

C07C 255/47 (2006.01) C07C 45/67 (2006.01) C07C 49/697 (2006.01) C07C 62/38 (2006.01) C07C 323/63 (2006.01) C07D 207/337 (2006.01) C07D 213/57 (2006.01) C07D 317/60 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1302420

ABSTRACT OF THE DISCLOSURE Disclosed are indene compounds of formula I: Image I wherein R1 is (a) a phenyl group optionally substituted; or (b) a bicyclic aromatic group, such as naphtnalene or quinoline; or (c) a heteroaromatic group selected from thiophene, pyridine and pyrrole, optionally substituted; wherein R2 i3 H, halogen, lower alkyl, benzyl, lower alkylthio, lower alkylsulfonyl, dilower alkylsulfamoyl, acylamino, benzylamino, dilower alkylamino, cyano, pyrrole, dilower alkylpyrrole, trifluoromethyl, methoxy, or tri- fluoromethoxy; wherein R3 is CN, COOR4, -CON(R4)2, or COR4, wherein R4 is a lower alkyl group, and "n" is an integer of 1-3 inclusive. A method for preparing such compounds is also disclosed. The compounds are useful as intermediates in the preparation of pharmacologically-active compounds and are distinguished from prior art compound by their unsuggested structure and utility.

553169

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