Indene spla2 inhibitors

Details Indene spla2 inhibitors Indene spla2 inhibitors

C - Chemistry, Metallurgy

07

C

C07C 235/78 (2006.01) A61K 31/19 (2006.01) A61K 31/33 (2006.01) A61K 31/66 (2006.01) C07C 45/46 (2006.01) C07C 45/65 (2006.01) C07C 49/755 (2006.01) C07C 59/64 (2006.01) C07C 59/72 (2006.01) C07C 69/734 (2006.01) C07C 235/32 (2006.01) C07C 243/32 (2006.01) C07C 309/51 (2006.01) C07C 323/41 (2006.01) C07C 327/40 (2006.01) C07D 207/337 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07F 9/38 (2006.01)

Patent

CA 2195432

A class of novel indene-1-functional compounds is disclosed together with the use of such indene compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are indene-1-acetamides, indene-1-acetic acid hydrazides, and indene-1- glyoxylamides.

Classe de nouveaux composés indène-1-fonctionnels, ainsi qu'utilisation desdits composés indène pour inhiber la libération induite par sPLA¿2? d'acides gras dans le traitement de troubles pathologiques tels que le choc septique. Lesdits composés sont des indène-1-acétamides, des hydrazides d'acide indène-1-acétique et des indène-1-glyoxylamides.

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