C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/60 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61P 3/04 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2345359
Polycyclic dihydrothiazoles, process for their preparation, and their use as pharmaceuticals The invention relates to polycyclic dihydrothiazoles, and to their physiologically tolerable salts and physiologically functional derivatives. Compounds of the formula I (see formula I) in which the radicals have the meanings indicated, and their physiologically tolerable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
L'invention concerne des composés de formule (I) dans laquelle Y désigne une liaison directe -H2, -CH2-CH2-; X désigne CH2, CH(CH3), CH(C2H5), CH(C3H7), CH(C6H5); R1, R1' désignent, indépendamment l'un de l'autre, H, F, Cl, Br, J, CF3, NO2, CN, COOH, COO(C1-C6)-alkyle, CONH(C1-C6)-alkyle, CON[(C1-C6)-alkyle]2, (C1-C6)-alkyle, (C2-C6)-alcényle, C2-C6)-alkinyle, O-(C1-C6)-alkyle, SO2-NH2, SO2NH(C1-C6)-alkyle, SO2N[(C1-C6)-alkyle]2, S-(C1-C6)-alkyle, S-(CH2)n-phényle, SO-(C1-C6)-alkyle, SO-(CH2)n-phényle, SO2-(C1-C6)-alkyle, SO2-(CH2)n-phényle, NH2, NH-(C1-C6)-alkyle, N((C1-C6)-alkyle)2, NH(C1-C7)-acyle, phényle, biphényle, O-(CH2)n-phényle, 1- ou 2-naphtyle, 2-, 3- ou 4-pyridyle, 2- ou 3-furanyle, 2- ou 3-thiényle, tétrazol-5-yle, 1,2,3-triazol-5-yle; R2 désigne H, (C1-C6)-alkyle, (C3-C6)-alkyle, (C3-C6)-cycloalkyle, (CH2)n-phényle, (CH2)n-thiényle, (CH2)n-pyridyle, (CH2)n-furyle, C(O)-(C1-C6)-alkyle, C(O)-(C3-C6)-cycloalkyle, C(O)-(CH2)n-phényle, C(O)-(CH2)n-thiényle, C(O)-(CH2)n-pyridyle, C(O)-(CH2)n-furyle; R3 désigne H, (C1-C6)-alkyle, F, CN, N3, O-(C1-C6)-alkyle, (CH2)n-phényle, (CH2)n-thiényle, (CH2)n-pyridyle, (CH2)n-furyle; R4 désigne (C1-C8)-alkyle, (C3-C7)-cycloalkyle, (C2-C6)-alcényle, (C2-C6)-alkinyle, (C4-C7)-cycloalcényle, (CH2)n-NR6R7, (CH2)n-aryle ou (CH2)n-hétéroaryle. L'invention concerne également les sels physiologiquement compatibles de ces composés et leurs dérivés physiologiquement fonctionnels, ainsi que leurs procédés de fabrication. Les composés sont utilisés, par exemple, comme agents anorexigènes.
Bickel Martin
Geisen Karl
Glombik Heiner
Jahne Gerhard
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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