Indenoisoquinolinone analogs and methods of use thereof

Details Indenoisoquinolinone analogs and methods of use thereof Indenoisoquinolinone analogs and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/473 (2006.01) A61K 31/4738 (2006.01) A61K 31/4741 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 217/24 (2006.01) C07D 401/12 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2620052

The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog.

La présente invention concerne des analogues d'indénoisoquinolinone, des composition comprenant une dose efficace d'un analogue d'indénoisoquinolinone et des méthodes destinées à traiter ou prévenir une maladie inflammatoire, une lésion de reperfusion, un diabète sucré, une complication diabétique, une lésion de réoxygénation résultant d'une transplantation d'organe, une affection ischémique, une maladie neurodégénérative, une insuffisance rénale, une maladie vasculaire, une maladie cardiovasculaire, un cancer, une complication de prématurité, une cardiomyopathie, une rétinopathie, une néphropathie, une neuropathie, un dysfonctionnement érectile ou une incontinence urinaire, et consistant à administrer, à un sujet le nécessitant, une dose efficace d'un analogue d'indénoisoquinolinone.

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