Indenoisoquinolinone analogs and methods of use thereof

Details Indenoisoquinolinone analogs and methods of use thereof Indenoisoquinolinone analogs and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/395 (2006.01) A61K 31/661 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2677046

The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog.

L'invention concerne des analogues d'indénoisoquinoléinone, des compositions comprenant une quantité efficace d'un analogue d'indénoisoquinoléinone et des procédés pour traiter ou prévenir une maladie inflammatoire, une lésion de reperfusion, un diabète sucré, une complication diabétique, une lésion de réoxygénation provenant de la transplantation d'organe, une affection ischémique, une maladie neurodégénérative, une insuffisance rénale, une maladie vasculaire, une maladie cardiovasculaire, un cancer, une complication de prématurité, une cardiomyopathie, une rétinopathie, une néphropathie, une neuropathie, un dysfonctionnement érectile ou une incontinence urinaire, comprenant l'administration à un sujet, nécessitant celle-ci, d'une quantité efficace d'un analogue d'indénoisoquinoléinone.

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