Indenothiazole derivative and process for preparing the same

Details Indenothiazole derivative and process for preparing the same Indenothiazole derivative and process for preparing the same

C - Chemistry, Metallurgy

07

D

260/266.4, 260/2

C07D 277/60 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1292226

ABSTRACT The invention relates to a novel indeno- thiazole derivative having the formula: Image (Ia) wherein X and Y are identical with, or different from, each other and are each hydrogen, halogen, lower alkyl having 1-6 carbon atoms or lower alkoxyl having 1-6 carbon atoms; n is an integer of from 0 to 4, Rl is hydrogen, lower alkyl having 1-6 carbon atoms or phenyl; R2 is lower alkyl having 1-6 carbon atoms, cyclohexyl, lower alkoxyl having 1-6 carbon atoms, alkenyl having 3-6 carbon atoms, phenyl, m-(l-piperi- dinylmethyl)-phenoxy, phenyl substituted by a halogen atom, hydroxyl, lower alkyl having 1-6 carbon atoms, lower alkoxyl group having 1-6 carbon atoms or tri- fluoromethyl group, an heterocyclic ring selected from the group consisting of pyridyl, pyridyl mono- or di- substituted by one or two lower alkyl having 1-6 carbon atoms and thiazolyl and cycloamino selected from the group consisting of morpholino, piperidino, pyrroli- dino, piperazino substituted by lower alkyl group having 1-6 carbon atoms and piperidino substituted by lower alkyl group having 1-6 carbon atoms; R3 is hydrogen, lower alkyl having 1-6 carbon atoms, acetyl or trifluoromethylcarbonyl, or R2 and R3 are combined to form a cycloamino selected from the group consisting of pyrrolidino, piperidino, morpholino and piperidino di-substituted by two lower alkyl having 1-6 carbon atoms. The indenothiazole derivative of the formula (Ia) is useful as a medicine having an excellent anti- ulcerative effect.

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