Individual 5-fluorouracile dose optimization in folfiri...

Details Individual 5-fluorouracile dose optimization in folfiri... Individual 5-fluorouracile dose optimization in folfiri...

A - Human Necessities

61

K

A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 39/395 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2738755

The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5 -FU dose administered by continuous infusion in patients treated by a FOLFIRI regimen or a similar regimen, based on the 5 -FU plasmatic concentration measured during the previous 5 -FU continu-ous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer pa-tient in which the 5 -FU dose administered in continuous infusion in each FOLFIRI or similar treatment cycle is optimized using the decision algorithm according to the invention.

La présente invention concerne le domaine de la médecine personnalisée améliorée. Plus précisément, la présente invention concerne un procédé d'optimisation progressive de la dose de 5-FU administrée par perfusion continue chez des patients traités suivant un schéma FOLFIRI ou un schéma posologique similaire, en fonction de la concentration plasmatique de 5-FU mesurée au cours de la perfusion continue de 5-FU précédente et d'un algorithme de décision susdécrit. La présente invention concerne également une méthode de traitement d'un patient atteint d'un cancer dans laquelle la dose de 5-FU administrée par perfusion continue lors de chaque cycle de traitement par FOLFIRI ou de traitement similaire est optimisé à l'aide de l'algorithme de décision selon l'invention.

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