Individual 5-fluorouracile dose optimization in folfox...

Details Individual 5-fluorouracile dose optimization in folfox... Individual 5-fluorouracile dose optimization in folfox...

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2738753

The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5 -FU dose administered by continuous infusion in patients treated by a FOLFOX regimen or a similar regimen, based on the 5 -FU plasmatic concentration measured during the previous 5 -FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5 -FU dose administered in continuous infusion in each FOLFOX or similar treatment cycle is optimized using the decision algorithm according to the invention.

La présente invention concerne le domaine de la médecine personnalisée améliorée. Plus précisément, la présente invention concerne une méthode d'optimisation progressive de la dose de 5-FU administrée par perfusion continue chez des patients traités par un schéma FOLFOX ou un schéma posologique similaire, en fonction de la concentration plasmatique de 5-FU mesurée au cours de la perfusion continue de 5-FU précédente et d'un algorithme de décision susdécrit. La présente invention concerne également une méthode de traitement d'un patient atteint d'un cancer dans laquelle la dose de 5-FU administrée par perfusion continue lors de chaque cycle de traitement par FOLFOX ou de traitement similaire est optimisé à l'aide de l'algorithme de décision selon l'invention.

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