C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2700978
Provided herein are methods for the use of gene expression profiling to determine whether an individual afflicted with cancer will respond to a therapy, and in particular to therapeutic agents such as platinum-based agents and antimetabolite agents. Methods for the treatment of individuals with the therapeutic agents are also provided. Methods of predicting the efficacy of cancer therapeutic agents such as platinum-based and antimetabolite therapeutic agents are also provided. Kits including gene chips and instructions for predicting responsiveness are also provided.
La présente invention concerne des procédés permettant l'utilisation du profil d'expression génique pour déterminer si un individu atteint d'un cancer sera sensible à un traitement, et en particulier à des agents thérapeutiques tels que des agents à base de platine et des agents anti-métabolites. L'invention concerne également des procédés pour le traitement d'individus avec les agents thérapeutiques. L'invention concerne également des procédés permettant de prédire l'efficacité d'agents thérapeutiques contre le cancer tels que des agents thérapeutiques à base de platine et des anti-métabolites. L'invention concerne également des kits comprenant des puces à gènes et des instructions pour prédire la sensibilité.
Dressman Holly K.
Nevins Joseph R.
Potti Anil
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Duke University
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